Article
Stability of replicative form and fitness among RNA variants transcribed by Qbeta replicase.
Proceedings. Biological sciences - 22 Apr 1995
Davis B K
Abstract excerpt
Stability in the replicative form of RNA molecules transcribed by Qbeta replicase was demonstrated to provide a sequence-dependent indicator of their fitness. This follows from the finding that replication rates reported for 17 RNA species (genome length, 77-370 nucleotides) correlate with the self-interaction free energy of these self-annealed strands. Formation of double-stranded molecules during replication...
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