Phenotypic traits and regulatory role of RNA folding in molecular selection.

Abstract excerpt

We concentrate on instances in which the phenotypic expression of information encoded in an RNA primary sequence might be revealed by the folding of the RNA itself. We have discovered that this situation finds concrete realization in the design of RNA molecules capable of maximizing the rate of autocatalytic synthesis when incubated with viral Q beta-replicase. This requires that we introduce the notion of...

Topics

• Algorithms
• Base Sequence
• Genotype
• Kinetics
• Mathematics
• Models, Structural
• Molecular Sequence Data
• Nucleic Acid Conformation
• Phenotype
• Q beta Replicase
• RNA, Viral
• Thermodynamics