Article
Semiconservative replication in the quasispecies model.
Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Jun 2004
Tannenbaum Emmanuel, Deeds Eric J, Shakhnovich Eugene I
Abstract excerpt
This paper extends Eigen's quasispecies equations to account for the semiconservative nature of DNA replication. We solve the equations in the limit of infinite sequence length for the simplest case of a static, sharply peaked fitness landscape. We show that the error catastrophe occurs when micro, the product of sequence length and per base pair mismatch probability, exceeds 2 ln [2/ ( 1+1/k ) ], where k>1 is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.