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Article

Structural transition of replicable RNAs during in vitro evolution with Qβ replicase.

RNA (New York, N.Y.) - 1 Jan 2020

Mizuuchi Ryo, Usui Kimihito, Ichihashi Norikazu

Abstract excerpt

Single-stranded RNAs (ssRNAs) are utilized as genomes in some viruses and also in experimental models of ancient life-forms, owing to their simplicity. One of the largest problems for ssRNA replication is the formation of double-stranded RNA (dsRNA), a dead-end product for ssRNA replication. A possible strategy to avoid dsRNA formation is to create strong intramolecular secondary structures of ssRNA. To design...

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Identifiers

PMID: 31690585
DOI: 10.1261/rna.073106.119
PMCID: PMC6913131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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