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Article

Absolute oral bioavailability of traxoprodil in cytochrome P450 2D6 extensive and poor metabolisers.

Clinical pharmacokinetics - 1 Jan 2006

Taylor Timothy J, Diringer Kelly, Russell Tanya, Venkatakrishnan Karthik, Wilner Keith, Crownover Penelope H, Benincosa Lisa J, Gibbs Megan A

Abstract excerpt

BACKGROUND: Traxoprodil, a substituted 4-phenylpiperidine, is an N-methyl-D-aspartate (NMDA) receptor antagonist that is selective for receptors containing the NR2B subunit. In vivo and in vitro studies examining the disposition of traxoprodil have demonstrated that it is mainly metabolised by cytochrome P450 (CYP) 2D6, a major drug-metabolising enzyme that exhibits a genetic polymorphism. OBJECTIVE: To assess...

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PMID: 16984212
DOI: 10.2165/00003088-200645100-00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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