Article
DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.
Cancer research - 1 Jun 1995
Branch P, Hampson R, Karran P
Abstract excerpt
DNA mismatch binding in vitro, resistance to DNA methylation damage, and spontaneous mutation rates were examined in human colorectal adenocarcinoma cell lines. Of 11 cell lines, 3 (DLD1, HCT15, and LoVo) were defective in mismatch binding. All three lines had a mutator phenotype. These properties indicate that DLD1 and HCT15 may, like LoVo, carry mutations in the mismatch recognition protein hMSH2. Mismatch...
Topics
- Adenocarcinoma
- Colorectal Neoplasms
- DNA Damage
- DNA Repair
- DNA, Neoplasm
- DNA, Satellite
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Methylation
- Methylnitrosourea
- Methyltransferases