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Article

Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.

Cancer research - 1 Dec 1996

Liu L, Markowitz S, Gerson S L

Abstract excerpt

Cells with the mutator phenotype are tolerant to methylating damage from N-methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanine, exhibit replication repair errors, and have recently been found to be mutant in mismatch repair (MMR). However, resistance of cell lines with these defects to clinically used chemotherapeutic agents and the relationship of this resistance to expression of O6-alkylguanine-DNA...

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Source

Identifiers

PMID: 8968088

Genes

AGT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.PMID 8968088Read ↗

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Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.Semantic proximity Read ↗

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DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.Semantic proximity Read ↗

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Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.Semantic proximity Read ↗

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Mismatch Repair Deficiency Does Not Mediate Clinical Resistance to Temozolomide in Malignant GliomaSemantic proximity Read ↗

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