Article
Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea.
Cancer research - 1 Dec 1996
Liu L, Markowitz S, Gerson S L
Abstract excerpt
Cells with the mutator phenotype are tolerant to methylating damage from N-methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanine, exhibit replication repair errors, and have recently been found to be mutant in mismatch repair (MMR). However, resistance of cell lines with these defects to clini...
Topics
- Antineoplastic Agents, Alkylating
- Carmustine
- Colonic Neoplasms
- DNA Adducts
- DNA Damage
- DNA Repair
- Dacarbazine
- Drug Resistance, Neoplasm
- Enzyme Inhibitors
- Guanine
- Humans
- Methylation
- Methyltransferases
- Microsatellite Repeats
- Mutation
- O(6)-Methylguanine-DNA Methyltransferase
- Phenotype
- Temozolomide