Article
TARGETING GENE EXPRESSION TO ENDOTHELIAL CELLS IN TRANSGENIC MICE USING THE HUMAN INTERCELLULAR ADHESION MOLECULE 2 PROMOTER1
1 Jul 1996
Abstract excerpt
Genetic engineering of donor animals in xenotransplantation research has been directed largely toward obtaining expression of various immunoregulatory molecules on vascular endothelium, the initial target of recipient antibody and complement. However, specific high-level expression of transgenes throughout the vascular tree in adult animals has proved difficult to achieve, perhaps because of the inherent...
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