Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple developmental roles of VEGF suggested by a LacZ-tagged allele.

Developmental biology - 15 Aug 1999

Miquerol L, Gertsenstein M, Harpal K, Rossant J, Nagy A

Abstract excerpt

Vascular endothelial growth factor (VEGF) is an angiogenic factor and a potent stimulator of microvascular permeability. It is a mitogen specific for endothelial cells. The expression of VEGF and its two receptors, Flk-1 and Flt-1, is pivotal for the proper formation of blood vessels in embryogenesis as shown by gene-targeting experiments. Interestingly, the loss of even a single allele of VEGF led to embryonic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular System
Share to Embryo Implantation
Share to Embryonic Induction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Growth Factors

Share to Genitalia, Female

Share to Receptors, Growth Factor

Share to Receptors, Vascular Endothelial Growth Factor

Share to Vascular Endothelial Growth Factors

Source

Identifiers

PMID: 10433823
DOI: 10.1006/dbio.1999.9355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple developmental roles of VEGF suggested by a LacZ-tagged allele.PMID 10433823Read ↗

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene.Semantic proximity Read ↗

Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors.Semantic proximity Read ↗

VEGF Receptor Signal TransductionSemantic proximity Read ↗

Insufficient VEGFA activity in yolk sac endoderm compromises haematopoietic and endothelial differentiation.Semantic proximity Read ↗

Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression.Semantic proximity Read ↗

Analysis of a zebrafish VEGF receptor mutant reveals specific disruption of angiogenesis.Semantic proximity Read ↗

Vasculogenesis and Angiogenesis in VEGF Receptor-1 Deficient Mice.Semantic proximity Read ↗

Genetic mosaics reveal mechanisms of resistance to VEGF signaling loss during angiogenesisSemantic proximity Read ↗

Distinct requirements for zebrafish angiogenesis revealed by a VEGF-A morphant.Semantic proximity Read ↗

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele.Semantic proximity Read ↗

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3Semantic proximity Read ↗

A comparative study of the expression patterns for vegf, vegf-b/vrf and vegf-c in the developing and adult mouseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.