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Article

P1 plasmid partition: binding of P1 ParB protein and Escherichia coli integration host factor to altered parS sites.

Biochimie - 1 Jan 1994

Funnell B E, Gagnier L

Abstract excerpt

The Escherichia coli integration host factor (IHF) participates in P1 plasmid partition by assisting the interaction of P1 ParB protein with its specific site, parS. Together they form an extremely high-affinity protein-DNA complex, in which parS DNA is wrapped around a core of ParB and IHF protein in a precise three-dimensional conformation. We have investigated the interaction of ParB and IHF with mutant DNA...

Topics

Bacterial Proteins
Base Sequence
Binding Sites
Biological Factors
Escherichia coli
Lysogeny
Molecular Sequence Data
Mutation
Plasmids
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7748936
DOI: 10.1016/0300-9084(94)90017-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7748936-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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P1 plasmid partition: binding of P1 ParB protein and Escherichia coli integration host factor to altered parS sites.PMID 7748936Read ↗

Transcriptional interference by a complex formed at the centromere-like partition site of plasmid P1.Semantic proximity Read ↗

Partition of P1 plasmids in Escherichia coli mukB chromosomal partition mutants.Semantic proximity Read ↗

Dissection of the ATPase active site of P1 ParA reveals multiple active forms essential for plasmid partition.Semantic proximity Read ↗

Fine-structure analysis of the P1 plasmid partition site.Semantic proximity Read ↗

Silencing of genes flanking the P1 plasmid centromere.Semantic proximity Read ↗

Specificity switching of the P1 plasmid centromere-like site.Semantic proximity Read ↗

The P1 ParA protein and its ATPase activity play a direct role in the segregation of plasmid copies to daughter cells.Semantic proximity Read ↗

Probing the N-terminus of ParB using cysteine-scanning mutagenesis and thiol modification.Semantic proximity Read ↗

A single parS sequence from the cluster of four sites closest to oriC is necessary and sufficient for proper chromosome segregation in Pseudomonas aeruginosa.Semantic proximity Read ↗

Altered ParA partition proteins of plasmid P1 act via the partition site to block plasmid propagation.Semantic proximity Read ↗

The role of Par proteins in the active segregation of the P1 plasmid.Semantic proximity Read ↗

Bacillus subtilis ParB C-terminal lysine residues are essential for dimerization and in vivo function, indicating their roles in DNA sliding.Semantic proximity Read ↗

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