Article
17q allele loss is associated with lymph node metastasis in locally aggressive human colorectal cancer.
The Journal of pathology - 1 Mar 1995
Purdie C A, Piris J, Bird C C, Wyllie A H
Abstract excerpt
A consecutive series of 87 colorectal tumours were studied for loss of a polymorphic probe on chromosome 17q and of the 64 informative cases, 13 (20 per cent) showed loss of heterozygosity (LOH). Examples of LOH were found in carcinomas of all stages and in a large non-invasive adenoma. There was no correlation between 17q LOH and patient age, sex, standard clinicopathological variables (differentiation and...
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