Article
Intramolecular signal transduction in c-Jun.
The EMBO journal - 1 May 1995
Papavassiliou A G, Treier M, Bohmann D
Abstract excerpt
The DNA-binding activity of c-Jun is determined by the phosphorylation state of a cluster of threonine and serine residues located near its COOH-terminus. We have analyzed the events that lead to c-Jun activation via dephosphorylation of these sites in response to phorbol esters. Our results indicate that COOH-terminal dephosphorylation is an indirect consequence of a separate phosphorylation event targeted to...
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