Article
Intramolecular signal transduction in c-Jun.
The EMBO journal - 1 May 1995
Papavassiliou A G, Treier M, Bohmann D
Abstract excerpt
The DNA-binding activity of c-Jun is determined by the phosphorylation state of a cluster of threonine and serine residues located near its COOH-terminus. We have analyzed the events that lead to c-Jun activation via dephosphorylation of these sites in response to phorbol esters. Our results indi...
Topics
- Amino Acid Sequence
- Binding Sites
- DNA
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Proto-Oncogene Proteins c-jun
- Signal Transduction