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Article

JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun.

The EMBO journal - 15 Jul 2003

Weiss Carsten, Schneider Sandra, Wagner Erwin F, Zhang Xiaohong, Seto Edward, Bohmann Dirk

Abstract excerpt

The AP-1 transcription factor c-Jun is a prototypical nuclear effector of the JNK signal transduction pathway. The integrity of JNK phosphorylation sites at serines 63/73 and at threonines 91/93 in c-Jun is essential for signal-dependent target gene activation. We show that c-Jun phosphorylation mediates dissociation of an inhibitory complex, which is associated with histone deacetylase 3 (HDAC3). The subsequent...

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Source

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Identifiers

PMID: 12853483
DOI: 10.1093/emboj/cdg364
PMCID: PMC165634

Genes

HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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