Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Septal cell lines derived from the trisomy 16 mouse: generation, characterization, and response to NGF.

Brain research - 13 Feb 1995

Kim J H, Hammond D N

Abstract excerpt

The trisomy 16 mouse is a genetic model of Down syndrome. Clonal cell lines were developed from trisomic as well as euploid embryonic mouse septal cells by introduction of thermolabile large T antigen mutant of SV 40. The cell lines underwent morphological differentiation at the non-permissive temperature and in response to a differentiating agent. Immunocytochemical staining indicated that cells of neuronal...

Topics

Animals
Antigens, Polyomavirus Transforming
Brain
Cell Differentiation
Cell Line
Clone Cells
Immunohistochemistry
Mice
Mutation
Nerve Growth Factors
Retroviridae
Trisomy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7743218
DOI: 10.1016/0006-8993(94)01359-p

Genes

NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7743218-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Septal cell lines derived from the trisomy 16 mouse: generation, characterization, and response to NGF.PMID 7743218Read ↗

The neuropathology of the trisomy 16 mouse.Semantic proximity Read ↗

Failure of Brain-Derived Neurotrophic Factor-Dependent Neuron Survival in Mouse Trisomy 16Semantic proximity Read ↗

Role of Founder Cell Deficit and Delayed Neuronogenesis in Microencephaly of the Trisomy 16 MouseSemantic proximity Read ↗

Proliferation deficits and gene expression dysregulation in Down's syndrome (Ts1Cje) neural progenitor cells cultured from neurospheres.Semantic proximity Read ↗

Partial IFN-alpha/beta and IFN-gamma receptor knockout trisomy 16 mouse fetuses show improved growth and cultured neuron viability.Semantic proximity Read ↗

Calcium signals in cell lines derived from the cerebral cortex of normal and trisomy 16 miceSemantic proximity Read ↗

An immortalized septal cell line that expresses trkA mRNA in response to basic fibroblast growth factor.Semantic proximity Read ↗

Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.Semantic proximity Read ↗

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalitiesSemantic proximity Read ↗

Autonomous trisomic rescue of Down syndrome cellsSemantic proximity Read ↗

Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndromeSemantic proximity Read ↗

Consequences of Trisomy 16 for Mouse Brain Development: Corticogenesis in a Model of Down SyndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.