Article
Septal cell lines derived from the trisomy 16 mouse: generation, characterization, and response to NGF.
Brain research - 13 Feb 1995
Kim J H, Hammond D N
Abstract excerpt
The trisomy 16 mouse is a genetic model of Down syndrome. Clonal cell lines were developed from trisomic as well as euploid embryonic mouse septal cells by introduction of thermolabile large T antigen mutant of SV 40. The cell lines underwent morphological differentiation at the non-permissive temperature and in response to a differentiating agent. Immunocytochemical staining indicated that cells of neuronal...
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