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Article

Failure of Brain-Derived Neurotrophic Factor-Dependent Neuron Survival in Mouse Trisomy 16

1 Apr 2002

Abstract excerpt

The neurotrophin, brain derived neurotrophic factor (BDNF), exerts multiple effects on the development and maintenance of the nervous system, including regulating synaptic plasticity and promoting neuron survival. Here we report the selective failure of BDNF-dependent survival in cultured hippocampal neurons from the trisomy 16 (Ts16) mouse, an animal model of Down syndrome. This failure is accompanied by...

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Identifiers

PMID: 11923422
DOI: 10.1523/jneurosci.22-07-02571.2002

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Source receipt: pubmed, retrieved 7 Sept 2026.

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