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Article

Autonomous trisomic rescue of Down syndrome cells

13 Feb 2019

Abstract excerpt

Down syndrome is the most frequent chromosomal abnormality among live-born infants. All Down syndrome patients have mental retardation and are prone to develop early onset Alzheimer's disease. However, it has not yet been elucidated whether there is a correlation between the phenotype of Down syndrome and the extra chromosome 21. In this study, we continuously cultivated induced pluripotent stem cells (iPSCs)...

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PMID: 30760866
DOI: 10.1038/s41374-019-0230-0

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