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Article

Consequences of Trisomy 16 for Mouse Brain Development: Corticogenesis in a Model of Down Syndrome

1 Oct 1996

Abstract excerpt

We have studied abnormalities in the tangential and radial expansion of the cerebral cortex during fetal development in the trisomy 16 (Ts16) mouse, a model for human trisomy 21 (Down syndrome). Slowed tangential expansion of the neuroepithelium in Ts16 resulted in a reduction of final telencephalic size and is predicted to decrease the number of radial cortical units in the mature brain. In addition, radial...

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Identifiers

PMID: 8815899
DOI: 10.1523/jneurosci.16-19-06175.1996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Consequences of Trisomy 16 for Mouse Brain Development: Corticogenesis in a Model of Down SyndromePMID 8815899Read ↗

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