Article
T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras.
European journal of immunology - 1 Apr 1995
Schneider H, Cai Y C, Prasad K V, Shoelson S E, Rudd C E
Abstract excerpt
The T cell molecule CD28 provides a co-stimulatory signal that is required for T cell proliferation, and has been implicated in the control of T cell anergy. An important clue to the signaling mechanism of CD28 is the finding that CD28 can bind to phosphatidylinositol 3-kinase (PI 3-kinase) by me...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Binding Sites
- CD28 Antigens
- GRB2 Adaptor Protein
- Humans
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Proteins
- Proto-Oncogene Proteins p21(ras)
- Second Messenger Systems
- Sequence Analysis
- Signal Transduction
- Son of Sevenless Proteins
- T-Lymphocytes
- Tumor Cells, Cultured