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Article

T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras.

European journal of immunology - 1 Apr 1995

Schneider H, Cai Y C, Prasad K V, Shoelson S E, Rudd C E

Abstract excerpt

The T cell molecule CD28 provides a co-stimulatory signal that is required for T cell proliferation, and has been implicated in the control of T cell anergy. An important clue to the signaling mechanism of CD28 is the finding that CD28 can bind to phosphatidylinositol 3-kinase (PI 3-kinase) by means of a cytoplasmic phospho-YMNM (pYMNM) motif. A remaining issue concerns whether CD28 can recruit other...

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Source

Identifiers

PMID: 7737275
DOI: 10.1002/eji.1830250428

Genes

GRB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras.PMID 7737275Read ↗

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The Role of the CD28 Family Receptors in T-Cell ImmunomodulationSemantic proximity Read ↗

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