Article
CD28 signaling in primary CD4(+) T cells: identification of both tyrosine phosphorylation-dependent and phosphorylation-independent pathways.
International immunology - 1 Dec 2013
Ogawa Shuhei, Watanabe Masashi, Sakurai Yuichi, Inutake Yu, Watanabe Shiho, Tai Xuguang, Abe Ryo
Abstract excerpt
In addition to TCR signaling, the activation and proliferation of naive T cells require CD28-mediated co-stimulation. Once engaged, CD28 is phosphorylated and can then activate signaling pathways by recruiting molecules to its YMNM motif and two PxxP motifs. In this study, we analyzed the relationship between tyrosine phosphorylation and the co-stimulatory function of CD28 in murine primary CD4(+) T cells....
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