Article
Mouse multidrug resistance 1a/3 gene is the earliest known endothelial cell differentiation marker during blood-brain barrier development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 1995
Qin Y, Sato T N
Abstract excerpt
Molecular mechanisms of endothelial cell differentiation during blood-brain barrier (BBB) development is not well understood due to the lack of specific molecular markers. Here we describe that expression of the mouse multidrug resistance 1a/3 (mdr1a/3) gene can be detected specifically in subsets of vascular endothelial cells associated with neural tissues at as early as embryonic day 10.5 (E10.5). This onset of...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Blood-Brain Barrier
- Brain
- Cell Differentiation
- Drug Resistance, Multiple
- Endothelium, Vascular
- Gene Expression Regulation, Developmental
- Mice
- Mice, Mutant Strains