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Brain barriers and functional interfaces with sequential appearance of ABC efflux transporters during human development

11 Sept 2017

Abstract excerpt

Adult brain is protected from entry of drugs and toxins by specific mechanisms such as ABC (ATP-binding Cassette) efflux transporters. Little is known when these appear in human brain during development. Cellular distribution of three main ABC transporters (ABCC1, ABCG2, ABCB1) was determined at blood-brain barriers and interfaces in human embryos and fetuses in first half of gestation. Antibodies against...

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PMID: 28912477
DOI: 10.1038/s41598-017-11596-0

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