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Article

CNS angiogenesis and barriergenesis occur simultaneously.

Developmental biology - 15 May 2017

Umans Robyn A, Henson Hannah E, Mu Fangzhou, Parupalli Chaithanyarani, Ju Bensheng, Peters Jennifer L, Lanham Kevin A, Plavicki Jessica S, Taylor Michael R

Abstract excerpt

The blood-brain barrier (BBB) plays a vital role in the central nervous system (CNS). A comprehensive understanding of BBB development has been hampered by difficulties in observing the differentiation of brain endothelial cells (BECs) in real-time. Here, we generated two transgenic zebrafish line, Tg(glut1b:mCherry) and Tg(plvap:EGFP), to serve as in vivo reporters of BBB development. We showed that...

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Identifiers

PMID: 28365243
DOI: 10.1016/j.ydbio.2017.03.017
PMCID: PMC5682946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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