Article
Post-irradiation somatic mutation and clonal stabilisation time in the human colon.
Gut - 1 Oct 1996
Campbell F, Williams G T, Appleton M A, Dixon M F, Harris M, Williams E D
Abstract excerpt
BACKGROUND: Colorectal crypts are clonal units in which somatic mutation of marker genes in stem cells leads to crypt restricted phenotypic conversion initially involving part of the crypt, later the whole crypt. Studies in mice show that the time taken for the great majority of mutated crypts to be completely converted, the clonal stabilisation time, is four weeks in the colon and 21 weeks in the ileum....
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