Unicryptal loss of heterozygosity in hereditary non-polyposis colorectal cancer.

doi:10.1080/00313029400169102

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Article

Unicryptal loss of heterozygosity in hereditary non-polyposis colorectal cancer.

Pathology - 1 Oct 1994

Jass J R, Edgar S

Abstract excerpt

DNA mismatch repair genes are responsible for the condition hereditary non-polyposis colorectal cancer (HNPCC). Genomic destabilization caused by failure of DNA mismatch repair leads to the progressive accumulation of somatic mutations and so to accelerated oncogenesis. The aim of this study was...

Topics

Acetyltransferases
Adult
Aged
Aged, 80 and over
Chromosome Deletion
Colorectal Neoplasms, Hereditary Nonpolyposis
Female
Genotype
Heterozygote
Humans
Intestinal Mucosa
Male
Middle Aged
Periodic Acid-Schiff Reaction

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