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Article

Unicryptal loss of heterozygosity in hereditary non-polyposis colorectal cancer.

Pathology - 1 Oct 1994

Jass J R, Edgar S

Abstract excerpt

DNA mismatch repair genes are responsible for the condition hereditary non-polyposis colorectal cancer (HNPCC). Genomic destabilization caused by failure of DNA mismatch repair leads to the progressive accumulation of somatic mutations and so to accelerated oncogenesis. The aim of this study was to document the rate of background mutational activity in the normal colorectal mucosa of subjects with HNPCC. A...

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Source

Identifiers

PMID: 7892041
DOI: 10.1080/00313029400169102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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