Article
A new mitochondrial DNA mutation associated with non-insulin-dependent diabetes mellitus.
Biochemical and biophysical research communications - 17 Apr 1995
Nakagawa Y, Ikegami H, Yamato E, Takekawa K, Fujisawa T, Hamada Y, Ueda H, Uchigata Y, Miki T, Kumahara Y
Abstract excerpt
Mitochondria play an important role in glucose-induced insulin secretion in pancreatic beta cells. We therefore examined whether patients with NIDDM exhibit genetic variability in mitochondrial DNA (mtDNA), a candidate gene for NIDDM. We sequenced mtDNA in the region encoding tRNALeu and the adja...
Topics
- Base Sequence
- DNA Primers
- DNA, Mitochondrial
- Diabetes Mellitus, Type 2
- Genes
- Humans
- Molecular Sequence Data
- Mutation