Article
Alterations in the structure of the EBV nuclear antigen, EBNA1, in epithelial cell tumours.
Oncogene - 20 Apr 1995
Snudden D K, Smith P R, Lai D, Ng M H, Griffin B E
Abstract excerpt
The EBV nuclear antigen, EBNA1, is the only viral protein consistently expressed in all virus-infected cells. It is required in trans for viral replication, maintenance of EBV extrachromosomal episomes, and transcriptional transactivation in latently-infected B-cells. It binds RNA suggestive of a regulatory role in post-transcriptional events and in transgenic mice, it is tumorigenic. In RNase protection studies...
Topics
- Amino Acid Sequence
- Antigens, Viral
- Base Sequence
- Carcinoma
- DNA
- DNA-Binding Proteins
- Epstein-Barr Virus Nuclear Antigens
- Humans
- Molecular Sequence Data
- Mutation
- Nasopharyngeal Neoplasms