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Article

Antigenic and sequence variation in the C-terminal unique domain of the Epstein-Barr virus nuclear antigen EBNA-1.

Virology - 20 Apr 1995

Wrightham M N, Stewart J P, Janjua N J, Pepper S D, Sample C, Rooney C M, Arrand J R

Abstract excerpt

The Epstein-Barr virus (EBV) nuclear antigen EBNA-1 is essential for viral genome maintenance in vitro and may be the only EBV protein expressed by the majority of latently infected cells in vivo. EBNA-1 may therefore be critical to the evasion of host immunity which allows persistent infection. EBNA-1 includes a polymorphic internal repeat domain of unknown significance and unique regions which mediate all known...

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Identifiers

PMID: 7538250
DOI: 10.1006/viro.1995.1183

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