Article
Variation in the sequence of Epstein Barr virus nuclear antigen 1 in normal peripheral blood lymphocytes and in Burkitt's lymphomas.
Oncogene - 4 Jul 1996
Bhatia K, Raj A, Guitierrez M I, Judde J G, Spangler G, Venkatesh H, Magrath I T
Abstract excerpt
We have examined sequence variations in the EBNA-1 protein of EBV in normal peripheral blood lymphocytes (PBL) and Burkitt's lymphomas (BL). We find two EBNA-1 strains P (prototype) and V (variant) which differ by 15 amino acids. Each strain has two subtypes defined by the amino acid at position...
Topics
- Amino Acid Sequence
- Antigens, Viral
- B-Lymphocytes
- Base Sequence
- Burkitt Lymphoma
- DNA-Binding Proteins
- Epstein-Barr Virus Nuclear Antigens
- Genetic Variation
- Herpesvirus 4, Human
- Humans
- Lymphocytes
- Molecular Sequence Data
- Polymerase Chain Reaction