The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila.

doi:10.1016/j.ydbio.2007.08.011

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Article

The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila.

Developmental biology - 15 Nov 2007

Sorrentino Richard Paul, Tokusumi Tsuyoshi, Schulz Robert A

Abstract excerpt

Drosophila has emerged as an important model system to discover and analyze genes controlling hematopoiesis. One regulatory network known to control hemocyte differentiation is the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) signal-transduction pathway. A constitutive activation mutation of the Janus kinase Hopscotch (hopscotch(Tumorous-lethal); hop(Tum-l)) results in a...

Topics

Animals
Animals, Genetically Modified
Cell Differentiation
Cell Proliferation
Drosophila Proteins
Drosophila melanogaster
GATA Transcription Factors
Gene Expression Regulation, Developmental
Genes, Tumor Suppressor
Hematopoietic System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hemocytes

Janus Kinases

Larva

Phenotype

Signal Transduction

Transcription Factors

Transgenes

Source

Open in PubMed

Identifiers

PMID: 17936744
DOI: 10.1016/j.ydbio.2007.08.011

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