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Article

Affinity of Tomopenem (CS-023) for penicillin-binding proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Mar 2009

Koga Tetsufumi, Sugihara Chika, Kakuta Masayo, Masuda Nobuhisa, Namba Eiko, Fukuoka Takashi

Abstract excerpt

Tomopenem (formerly CS-023), a novel 1beta-methylcarbapenem, exhibited high affinity for penicillin-binding protein (PBP) 2 in Staphylococcus aureus, PBP 2 in Escherichia coli, and PBPs 2 and 3 in Pseudomonas aeruginosa, which are considered major lethal targets. Morphologically, tomopenem induced spherical forms in E. coli and short filamentation with bulges in P. aeruginosa, which correlated with the drug's PBP...

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Identifiers

PMID: 19104025
DOI: 10.1128/AAC.01433-08
PMCID: PMC2650550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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