Article
Interplay of impermeability and chromosomal beta-lactamase activity in imipenem-resistant Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy - 1 Sept 1992
Livermore D M
Abstract excerpt
Mutational loss of the D2 porin causes imipenem resistance in Pseudomonas aeruginosa. It was found that this mechanism could function only when the chromosomal beta-lactamase was expressed. Mutants lacking both the beta-lactamase and the D2 porin were almost as susceptible as those that lacked the beta-lactamase but retained the porin. Thus, imipenem resistance reflected an interplay of the enzyme and...
Topics
- Bacterial Outer Membrane Proteins
- Chromosomes, Bacterial
- Drug Resistance, Microbial
- Imipenem
- Microbial Sensitivity Tests
- Mutation
- Permeability
- Phenotype
- Porins
- Pseudomonas aeruginosa
- beta-Lactamases