Differential allelic expression of the type II collagen gene (COL2A1) in osteoarthritic cartilage.

Article

Differential allelic expression of the type II collagen gene (COL2A1) in osteoarthritic cartilage.

American journal of human genetics - 1 May 1995

Loughlin J, Irven C, Athanasou N, Carr A, Sykes B

Abstract excerpt

Osteoarthritis (OA) is a common debilitating disease resulting from the degeneration of articular cartilage. The major protein of cartilage is type II collagen, which is encoded by the COL2A1 gene. Mutations at this locus have been discovered in several individuals with inherited disorders of car...

Topics

Alleles
Cartilage, Articular
Collagen
Female
Gene Expression
Genetic Markers
Genotype
Humans
Knee
Male
Middle Aged
Osteoarthritis
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
RNA, Messenger

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