Article
Allele dependent silencing of COL1A2 using small interfering RNAs.
International journal of medical sciences - 1 Jan 2008
Lindahl Katarina, Rubin Carl-Johan, Kindmark Andreas, Ljunggren Osten
Abstract excerpt
Osteogenesis imperfecta (OI) is generally caused by a dominant mutation in Collagen I, encoded by the genes COL1A1 and COL1A2. To date there is no satisfactory therapy for OI, but inactivation of the mutant allele through small interfering RNAs (siRNA) is a promising approach, as siRNAs targeting each allele of a polymorphism could be used for allele-specific silencing irrespective of the location of the actual...
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