Article
Standpoint on imprinting of BCR and ABL.
Leukemia - 1 Apr 1995
Fioretos T, Heisterkamp N, Groffen J
Abstract excerpt
Cytogenetic studies of Ph-positive leukemic patients and their parents have indicated that chromosome 22 involved in the formation of the t(9;22) is of maternal origin, whereas chromosome 9 is preferentially of paternal origin. These data have suggested that the two genes BCR and ABL, which become fused through the translocation, might be imprinted, ie expressed in a parental-specific manner. Recent molecular...
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