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Article

TNF: A Tumor-Suppressing Factor or a Tumor-Promoting Factor?

13 Dec 2010

Abstract excerpt

Evaluation of: Cordero JB, Macagno JP, Stefanatos RK, Strathdee KE, Cagan RL, Vidal M: Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev. Cell 18, 999–1011 (2010). TNF-α is a major inflammatory cytokine named for its ability to induce rapid hemorrhagic necrosis of experimental cancers. During efforts to harness this antitumor activity in cancer treatments in the 1980s, a...

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Identifiers

PMID: 21142857
DOI: 10.2217/fon.10.155

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