Article
Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons.
The Journal of cell biology - 27 Jul 1998
Matsuoka Y, Li X, Bennett V
Abstract excerpt
Adducin is a heteromeric protein with subunits containing a COOH-terminal myristoylated alanine-rich C kinase substrate (MARCKS)-related domain that caps and preferentially recruits spectrin to the fast-growing ends of actin filaments. The basic MARCKS-related domain, present in alpha, beta, and...
Topics
- Actins
- Animals
- Base Sequence
- Binding Sites
- Calmodulin-Binding Proteins
- Cattle
- Cells, Cultured
- Cytoskeleton
- DNA Primers
- Dendrites
- Enzyme Activation
- Hippocampus
- Humans
- Intracellular Signaling Peptides and Proteins
- Macromolecular Substances