Article
Stability of an expanded trinucleotide repeat in the androgen receptor gene in transgenic mice.
Nature genetics - 1 Feb 1995
Bingham P M, Scott M O, Wang S, McPhaul M J, Wilson E M, Garbern J Y, Merry D E, Fischbeck K H
Abstract excerpt
The expansion of trinucleotide repeat sequences underlies a number of hereditary neurological disorders. To study the stability of a trinucleotide repeat and to develop an animal model of one of these disorders, spinal and bulbar muscular atrophy (SBMA), we have generated transgenic mice carrying either the normal or expanded repeat human androgen receptor (AR) gene. Unlike the disease allele in humans, the AR...
Topics
- Animals
- Base Sequence
- Female
- Gene Expression
- Male
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Molecular Structure
- Muscular Atrophy, Spinal
- Mutation