Article

A phenotypically robust model of Spinal and Bulbar Muscular Atrophy in <i>Drosophila</i>

2023-03-27

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is an X-linked disorder that affects males who inherit the androgen receptor ( AR ) gene with an abnormal CAG triplet repeat expansion. The resulting protein contains an elongated polyglutamine (polyQ) tract and causes motor neuron degeneration in an androgen-dependent manner. The precise molecular sequelae of SBMA are unclear. To assist with its investigation and the id...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4a5dc3b3-7ad4-51d2-a36f-3804e05488d4
DOI: 10.1101/2023.03.25.534140

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A phenotypically robust model of Spinal and Bulbar Muscular Atrophy in <i>Drosophila</i>DOI 10.1101/2023.03.25.534140Read

Transgenic mouse models of spinal and bulbar muscular atrophy (SBMA).Semantic proximity Read

Molecular Mechanisms and Therapeutics for SBMA/Kennedy's DiseaseSemantic proximity Read

<i>Drosophila</i> as an <i>In Vivo</i> Model for Human Neurodegenerative DiseaseSemantic proximity Read

A mouse model of spinal and bulbar muscular atrophy.Semantic proximity Read

Loss of endogenous androgen receptor protein accelerates motor neuron degeneration and accentuates androgen insensitivity in a mouse model of X-linked spinal and bulbar muscular atrophy.Semantic proximity Read

Muscle expression of mutant androgen receptor accounts for systemic and motor neuron disease phenotypes in spinal and bulbar muscular atrophy.Semantic proximity Read

Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscleSemantic proximity Read

[Molecular-targeted therapies for spinal and bulbar muscular atrophy].Semantic proximity Read

A family with early-onset and rapidly progressive X-linked spinal and bulbar muscular atrophy.Semantic proximity Read

Expression of expanded repeat androgen receptor produces neurologic disease in transgenic mice.Semantic proximity Read

Insights into Dentatorubral-Pallidoluysian Atrophy from a new <i>Drosophila</i> model of diseaseSemantic proximity Read

Early pathogenesis of spinal and bulbar muscular atrophy uncovered by human iPSC-derived motor neurons highlights pathogenic neuropeptides as therapeutic targetsSemantic proximity Read