Article
Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability.
Human molecular genetics - 1 Jun 1998
La Spada A R, Peterson K R, Meadows S A, McClain M E, Jeng G, Chmelar R S, Haugen H A, Chen K, Singer M J, Moore D, Trask B J, Fischbeck K H, Clegg C H, McKnight G S
Abstract excerpt
X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a CAG repeat expansion in the first exon of the androgen receptor (AR) gene. Disease-associated alleles (37-66 CAGs) change in length when transmitted from parents to offspring, with a significantly greater tendency to shift size when inherited paternally. As transgenic mice carrying human AR cDNAs with 45 and 66 CAG repeats do not display repeat...
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