Article
Basic fibroblast growth factor increases the number of excitatory neurons containing glutamate in the cerebral cortex.
Cerebral cortex (New York, N.Y. : 1991) - 1 Jan 2000
Vaccarino F M, Schwartz M L, Hartigan D, Leckman J F
Abstract excerpt
Stem cells isolated from the ventricular zone of embryonic day 12.5 rat telencephalon progressively proliferate and differentiate in vitro into three major classes of amino acid-containing neurons, glutamate, aspartate, and GABA. We quantitatively examined the effect of basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) on amino acid-containing neurons. bFGF caused a threefold increase in...
Topics
- Animals
- Brain Chemistry
- Bromodeoxyuridine
- Cell Division
- Cells, Cultured
- Cerebral Cortex
- Fibroblast Growth Factor 2
- Glutamic Acid
- Image Processing, Computer-Assisted
- Immunohistochemistry
- Nerve Growth Factors