Article
Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Nov 2008
Reyes Jeannie H, O'Shea K Sue, Wys Noel L, Velkey J Matthew, Prieskorn Diane M, Wesolowski Karolina, Miller Josef M, Altschuler Richard A
Abstract excerpt
Differentiation of the pluripotent neuroepithelium into neurons and glia is accomplished by the interaction of growth factors and cell-type restricted transcription factors. One approach to obtaining a particular neuronal phenotype is by recapitulating the expression of these factors in embryonic stem (ES) cells. Toward the eventual goal of auditory nerve replacement, the aim of the current investigation was to...
Topics
- Animals
- Basic Helix-Loop-Helix Proteins
- Biomarkers
- Brain-Derived Neurotrophic Factor
- Cell Differentiation
- Cell Line
- Cells, Cultured
- Cochlear Nerve
- Deafness