Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 5 Jul 2017

McCulloch Katherine A, Qi Yingchuan B, Takayanagi-Kiya Seika, Jin Yishi, Cherra Salvatore J

Abstract excerpt

Acetylcholine (ACh) receptors (AChR) regulate neural circuit activity in multiple contexts. In humans, mutations in ionotropic acetylcholine receptor (iAChR) genes can cause neurological disorders, including myasthenia gravis and epilepsy. In Caenorhabditis elegans, iAChRs play multiple roles in the locomotor circuit. The cholinergic motor neurons express an ACR-2-containing pentameric AChR (ACR-2R) comprised of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholinergic Neurons

Share to ACR gene

Share to Locomotion

Share to Mutation

Share to Receptors, Cholinergic

Share to Synaptic Transmission

Source

Open in PubMed Open full text

Identifiers

PMID: 28468816
DOI: 10.1534/g3.117.042598
PMCID: PMC5499116

Genes

ACR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation in Caenorhabditis elegans.PMID 28468816Read ↗

A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans.Semantic proximity Read ↗

TRPM channels modulate epileptic-like convulsions via systemic ion homeostasis.Semantic proximity Read ↗

Neuronal transcriptome analyses reveal novel neuropeptide modulators of excitation and inhibition imbalance in C. elegans.Semantic proximity Read ↗

Neuronal transcriptome analyses reveal novel neuropeptide modulators of excitation and inhibition imbalance in <i>C. elegans</i>Semantic proximity Read ↗

The sarco(endo)plasmic reticulum calcium ATPase SCA-1 regulates the Caenorhabditis elegans nicotinic acetylcholine receptor ACR-16.Semantic proximity Read ↗

ACR-12 ionotropic acetylcholine receptor complexes regulate inhibitory motor neuron activity in Caenorhabditis elegans.Semantic proximity Read ↗

Functional analysis of epilepsy-associated GABAA receptor mutations using Caenorhabditis elegans.Semantic proximity Read ↗

The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction.Semantic proximity Read ↗

Interacting genes required for pharyngeal excitation by motor neuron MC in Caenorhabditis elegans.Semantic proximity Read ↗

Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network.Semantic proximity Read ↗

Disruption of genes associated with Charcot-Marie-Tooth type 2 lead to common behavioural, cellular and molecular defects in Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans provides an efficient drug screening platform for GNAO1-related disorders and highlights the potential role of caffeine in controlling dyskinesia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.