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Article

The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans.

Genetics - 1 Feb 1995

Ellis R E, Kimble J

Abstract excerpt

In the nematode Caenorhabditis elegans, germ cells normally adopt one of three fates: mitosis, spermatogenesis or oogenesis. We have identified and characterized the gene fog-3, which is required for germ cells to differentiate as sperm rather than as oocytes. Analysis of double mutants suggests that fog-3 is absolutely required for spermatogenesis and acts at the end of the regulatory hierarchy controlling sex...

Topics

Animals
Base Sequence
Caenorhabditis elegans
Chromosome Mapping
Female
Genes, Helminth
Genes, Regulator
Genetic Complementation Test
Germ Cells
Male
Models, Genetic
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oogenesis

Phenotype

Sex Differentiation

Spermatogenesis

Source

Open in PubMed Open full text

Identifiers

PMID: 7713418
DOI: 10.1093/genetics/139.2.561
PMCID: PMC1206367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7713418-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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