Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program.

Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011

Lee Myon-Hee, Kim Kyung Won, Morgan Clinton T, Morgan Dyan E, Kimble Judith

Abstract excerpt

FOG-3, the single Caenorhabditis elegans Tob/BTG protein, directs germ cells to adopt the sperm fate at the expense of oogenesis. Importantly, FOG-3 activity must be maintained for the continued production of sperm that is typical of the male sex. Vertebrate Tob proteins have antiproliferative activity and ERK phosphorylation of Tob proteins has been proposed to abrogate "antiproliferative" activity. Here we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oocytes

Share to Phosphoproteins

Share to Phosphoric Monoester Hydrolases

Share to Spermatogenesis

Share to Spermatozoa

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 21571637
DOI: 10.1073/pnas.1106027108
PMCID: PMC3107262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program.PMID 21571637Read ↗

The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans.Semantic proximity Read ↗

Developmental expression of FOG-1/CPEB protein and its control in the Caenorhabditis elegans hermaphrodite germ line.Semantic proximity Read ↗

An RNA binding polymer specifies nematode sperm fateSemantic proximity Read ↗

C. elegans FOG-3/Tob can either promote or inhibit germline proliferation, depending on gene dosage and genetic context.Semantic proximity Read ↗

fog-2 and the evolution of self-fertile hermaphroditism in Caenorhabditis.Semantic proximity Read ↗

TRA-1A regulates transcription of fog-3, which controls germ cell fate in C. elegans.Semantic proximity Read ↗

fog-1, a regulatory gene required for specification of spermatogenesis in the germ line of Caenorhabditis elegans.Semantic proximity Read ↗

Sex Determination in Nematode Germ CellsSemantic proximity Read ↗

Dose-dependent control of proliferation and sperm specification by FOG-1/CPEBSemantic proximity Read ↗

Regulation of cell fate in Caenorhabditis elegans by a novel cytoplasmic polyadenylation element binding protein.Semantic proximity Read ↗

In Caenorhabditis elegans, the RNA-binding domains of the cytoplasmic polyadenylation element binding protein FOG-1 are needed to regulate germ cell fates.Semantic proximity Read ↗

FOG-2, a novel F-box containing protein, associates with the GLD-1 RNA binding protein and directs male sex determination in the C. elegans hermaphrodite germline.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.