Article
TRA-1A regulates transcription of fog-3, which controls germ cell fate in C. elegans.
Development (Cambridge, England) - 1 Jul 2000
Chen P, Ellis R E
Abstract excerpt
In C. elegans, the zinc-finger protein TRA-1A is thought to be the final arbiter of somatic sexual identity. We show that fog-3, which is required for germ cells to become sperm rather than oocytes, is a target of TRA-1A. First, northern analyses and RT-PCR experiments indicate that expression of fog-3 is controlled by tra-1. Second, studies of double mutants show that this control could be direct. Third, the...
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