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The macroheterogeneity of recombinant human interferon-gamma produced by Chinese-hamster ovary cells is affected by the protein and lipid content of the culture medium.

Biotechnology and applied biochemistry - 1 Feb 1995

Castro P M, Ison A P, Hayter P M, Bull A T

Abstract excerpt

The culture environment exerts a major effect on the glycosylation pattern of recombinant human interferon-gamma (IFN-gamma) produced by Chinese-hamster ovary (CHO) cells. The recombinant IFN-gamma is heterogeneous and consists of a mixture of fully (2N), partially (1N) and non-glycosylated (0N) glycoforms, and throughout batch cultures there is a decline in the proportion of fully glycosylated IFN-gamma. Glucose...

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PMID: 7710705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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