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Effect of different cell culture media on the production and glycosylation of a monoclonal antibody from a CHO cell line

22 Mar 2025

Abstract excerpt

Recombinant monoclonal antibodies (mAbs) are commonly produced using Chinese hamster ovary (CHO) cells and the cell culture medium used in bioreactors influences the yield and quality attributes of the protein drug products. The COVID 19 pandemic revealed a vulnerability in the supply chain for necessary reagents (such as culture medium and raw material) for maintaining un-interrupted production of protein drugs...

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PMID: 40124126
DOI: 10.1007/s10616-025-00733-7

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