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Article

N‐linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

1 Jan 2009

Abstract excerpt

We studied the variations in N-linked glycosylation of human IgG molecules derived from 105 different stable cell lines each expressing one of the six different antibodies. Antibody expression was based on glutamine synthetase selection technology in suspension growing CHO-K1SV cells. The glycans detected on the Fc fragment were mainly of the core-fucosylated complex type containing zero or one galactose and...

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PMID: 19224598
DOI: 10.1002/btpr.92

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