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Amino acid and glucose metabolism in fed‐batch CHO cell culture affects antibody production and glycosylation

12 Sept 2014

Abstract excerpt

Fed-batch Chinese hamster ovary (CHO) cell culture is the most commonly used process for IgG production in the biopharmaceutical industry. Amino acid and glucose consumption, cell growth, metabolism, antibody titer, and N-glycosylation patterns are always the major concerns during upstream process optimization, especially media optimization. Gaining knowledge on their interrelations could provide insight for...

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PMID: 25220616
DOI: 10.1002/bit.25450

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