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Impact of cell culture media additives on IgG glycosylation produced in Chinese hamster ovary cells

15 Dec 2018

Abstract excerpt

Glycosylation is a key critical quality attribute for monoclonal antibodies and other recombinant proteins because of its impact on effector mechanisms and half-life. In this study, a variety of compounds were evaluated for their ability to modulate glycosylation profiles of recombinant monoclonal antibodies produced in Chinese hamster ovary cells. Compounds were supplemented into the cell culture feed of...

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PMID: 30552760
DOI: 10.1002/bit.26904

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